Causes of chronic renal failure
* Diabetes. Diabetes mellitus is a leading cause of chronic kidney failure in the United States.
* High blood pressure (hypertension). Elevated blood pressure can damage the glomeruli and ultimately cause the nephrons containing damaged glomeruli to lose their ability to filter waste from your blood.
* Obstruction of urine flow. An enlarged prostate, kidney stones or tumors, or vesicoureteral reflux — a condition that results when urine backs up into your kidneys from your bladder — can block urine flow, increasing pressure in your kidneys and reducing their function.
* Kidney diseases. These include clusters of cysts in the kidneys (polycystic kidney disease), kidney infection (pyelonephritis) and inflammation of the glomeruli (glomerulonephritis), a condition that causes your kidneys to leak protein into your urine and damages nephrons.
* Kidney artery stenosis. This is a narrowing or blockage of the kidney (renal) artery before it enters your kidney, which impairs blood flow and leads to kidney damage.
* Toxins. Ongoing exposure to fuels and solvents, such as carbon tetrachloride, and lead — in lead-based paint, lead pipes, soldering materials, jewelry and even alcohol distilled in old car radiators — can lead to chronic kidney failure.
References
• Mayoclinic.com
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